2种癫痫治疗方案的药物经济学及安全性研究

.药事.

Phorrnoceuticol Administration China Pharmaceuticals 2018年4月20日第27卷第8期

Vol . 27, No . 8, April 20, 2018

?合理用药? d o i : 10. 3969z /j . issn . 1006 -4931. 2018. 08. 029

2种癫痫治疗方案的药物经济学及安全性研究*

何小群,黄晓华,黄慧,黄忠彪,陆高翔

(右江民族医学院附属医院,广西百色533000)

摘要:目的比较2种方案治疗癫痫的成本-效果比及安全性。方法采用回顾性研究方法,选择2014年7月至2016年7月接受治疗 的癫痫患者60例,按治疗方案的不同分为观察组和对照组,各3 0例。观察组患者给予丙戌酸钠缓释片、奥拉西坦注射液、注射用盐酸 川芎嗪治疗;对照组患者给予卡马西平片、奥拉西坦注射液、注射用长春西汀治疗。治疗14 d 后,观察两组患者的疗效,并运用药物经 济学成本-效果分析法计算治疗成本。结果观察组和对照组的总有效率分别为90. 00%和86. 67%,每例平均成本分别为1 580. 18元 和1 414. 88元,成本-效果比分别为17.56和16. 32;观察组出现恶心、短暂性脱发各1例,对照组出现白细胞减少、过敏性皮炎各 2例,头晕1例。结论对照组用药方案的成本-效果比观察组更佳,但观察组用药方案安全性更高。

关键词:癫痫;卡马西平;丙戌酸钠;成本-效果分析;药物经济学;安全性

中图分类号:R 956;R 969.3;R 971+.6 文献标识码:A 文章编号:1006-4931 牗018)08 -0088-03

Study on Pharmacoeconomics and Safety of Two Therapeutic Regimens for Epilepsy

He Xiaoqun , Huang Xiaohua , Huang Hui , Huang Zhongbiao , Lu

i Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , Guangxi ’China 533000)

A b s tra c t : O bjective To compare the cost - effectiveness and safety of two therapeutic regimens for epilepsy . M ethods The retro -spective study method was adopted , 60 patients with epilepsy treated in our hospital from July 2014 to July 2016 were selected and divided into the observation group and the control group according to the different therapeutic regm ens , 30 cases in each group . The observation group was treated with Compound Sodium Valproate and Valproic Acid Sustained Release Tablets , Oxiracetam Injection and Ligustrazine Hydrochloride for Injection , while the control goup was treated w ith Carbamazepine Tablets , Oxiracetam Injection and V in -pocetine for Injection . After 14 d of treatment , the curative effects of the two groups were observed , and the cost of treatment was cal -culated by the pharmacoeconomics cost - effectiveness analysis method . Results In the observation group and control group , the total ef -fective rates were 90.00% and 86. 67% , respectively ,the average costs per case were 1 550. 18 Yuan and 1 414.88 Yuan , respective -ly ,and the cost - effectiveness ratios were 17.56 and 16. 32 , respectively . There was 1 case of nausea and 1 case of transient hair loss in the observation group , while 2 cases of

leukocyte reduction , 2 cases of allergic dermatitis and 1 case of dizziness in the con group . C onclusion The cost - effectiveness of the control group was better than that of the observation goup , but the safety of the therapeutic regimens in the observation group was higher .

K e y w ords : epilepsy ; carbamazepine ; sodium valproate ; cost - effectiveness analysis ; pharmacoeconomics ; safety

癫痫为多种病因引起的慢性脑部疾病,儿童和青少年。但研究显示,近年来随着我国人口老龄化加剧,脑血管*基金项目:广西医药卫生自筹经费计划课题犤2015084];广西中医药民族医药自筹经费科研课题[GZZC 14 - 65犦

第一作者:何小群,女,壮族,硕士研究生,副主任药师,研究方向为医院药学与临床药学,(电话)0776-*******(电子信箱)hexiao . qun @163. com 。

犤]张静,何丽,常利慊.临床药师在糖尿病治疗中的药学

服务犤].医药卫生(文摘版),2016,5(1):75.

犤]杜娟.他汀类药物用于预防和治疗糖尿病多种并发症的

研究进展犤].中国临床药学杂志,2011,20(1):58 -60.

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(收稿日期=2017 -11 -26)88

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