Teneligliptin hydrobromide_906093-29-6_DataSheet_MedChemExpress
P d D Sh Product Name:
Teneligliptin hydrobromide CAS No.:
906093-29-6Cat. No.:
HY-14806A
Product Data Sheet
MWt:
1257.72Formula:
C44H65Br5N12O2S2Purity :>98%
Solubility:
DMSO
Mechanisms:
Biological Activity:
Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively
Pathways:Metabolism/Protease; Target:DPP4g p p g g p p y p p p y inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of
approximately 1 nM.
IC50 value: 1 nM [1]
Target: DPP4in vitro: Teneligliptin is a novel chemotype prolylthiazolidine-based DPP-4 inhibitor. The present study aimed to characterize the pharmacological profiles of teneligliptin in vitro and in vivo.
Teneligliptin competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in
vitro, with IC(50) values of approximately 1 nmol/l [1].i i O l d i i t ti f t li li ti i Wi t t lt d i th i hibiti f l DPP 4References:
[1]. Fukuda-Tsuru S, et al. A novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor,teneligliptin, improves postprandial hyperglycemia and dyslipidemia after single and repeated administrations Eur J Pharmacol 2012Dec 5;696(13):194202in vivo: Oral administration of teneligliptin in Wistar rats resulted in the inhibition of plasma DPP-4with an ED(50) of 0.41 mg/kg. Plasma DPP-4 inhibition was sustained even at 24h after administration of teneligliptin. An oral carbohydrate-loading test in Zucker fatty rats showed ... administrations. Eur J Pharmacol. 2012 Dec 5;696(1-3):194-202.
[2]. Fukuda-Tsuru S, et al. The novel dipeptidyl peptidase-4 inhibitor teneligliptin prevents high-fat diet-induced obesity accompanied with increased energy expenditure in mice. Eur J Pharmacol.
2014 Jan 15;723:207-15.Caution: Not fully tested. For research purposes only
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