什么是胚胎植入前基因检测

什么是胚胎植入前基因检测(PGT)

植入前的基因测试可以筛查遗传疾病和染色体异常，增加试管婴儿患者成功怀孕的几率，生一个健康的宝宝。

为了增加怀孕和拥有一个没有遗传疾病和染色体疾病的健康婴儿的几率，爱嗣国际合作的生殖中心提供植入前基因测试，以配合IVF治疗。随着父母年龄的增长，孩子患唐氏综合症或染色体异常等遗传疾病导致流产的可能性会增加。另外，如果患者是遗传疾病的携带者，那么有可能遗传给孩子或者影响生育能力。植入前基因检测解决了这些挑战，防止遗传疾病和染色体异常的遗传。

原理：

植入前基因检测筛选能够让医生选择最健康的胚胎植入。传统的体外受精会导致多胎妊娠，比如双胞胎甚至三胞胎，而胚胎植入前的基因测试使我们能够只移植一个胚胎，帮助患者一次只怀上一个孩子。

植入前基因检测有两种形式，分别称为植入前基因诊断(PGD)和植入前基因筛查(PGS)。

植入前基因诊断(PGD)

如果患者有已知的遗传疾病，如地中海贫血或血友病，那么就可以考虑PGD，有的生殖中心采用更先进的PGD技术，称为核型定位，来选择没有遗传的胚胎，这样患者就可以拥有一个健康的宝宝。

马来西亚的生殖中心尤其重视对地中海贫血(Thalassemia)进行筛查。地中海贫血是一种严重的血液疾病，每20名马来西亚人中就有一人是携带者，主要是华裔。当父母双方都是携带者时，有25%的孩子会患上严重的地中海贫血。PGD有效地阻止了地中海贫血基因遗传给后代。

植入前基因筛查(PGS)

PGS是一种使用作下一代试管治疗的一部分的技术，以确保患者的胚胎有正常的染色体数目，以提高试管婴儿患者成功怀孕的机会，并有一个健康的宝宝。

统计数据显示，五分之一的妊娠以流产告终，超过50%的流产是由染色体异常引起的。染色体异常还会导致遗传疾病，如唐氏综合症、爱德华综合症、帕托综合症、特纳综合症和任何与性别有关的疾病。

通过PGS，我们筛选，选择和转移最强壮的胚胎免于染色体异常。它可以防止多胎妊娠，因为我们可以移植单个胚胎，而不是移植多个质量不一的胚胎。

基于这个原因，我们推荐NextGen IVF技术用于年龄较大的夫妇、有流产史或试管受精失败的夫妇、或希望避免多次怀孕但同时提高成功率的夫妇。

Preimplantation Genetic Testing (PGT) Preimplantation genetic testing screens for genetic disorders and abnormalities and increases your chances of successfully conceiving a healthy baby.

For your peace of mind.

To increase your chances of conceiving and having a healthy baby free from genetic diseases and chromosome disorders, we offer Preimplantation Genetic Testing to be used in conjunction with IVF treatment.

The possibility of having a baby with a genetic condition such as Down syndrome or chromosome abnormality that can cause miscarriage, increases with age.

Alternatively, if you’re a carrier of a genetic disorder, there is a risk it can be passed on to your baby or affect your ability to conceive.

Preimplantation Genetic Testing resolves these challenges, preventing the transmission of genetic diseases and chromosome abnormalities.

How it works

Preimplantation Genetic Testing screens for genetic conditions and allows us to choose the healthiest embryo for implantation. While traditional forms of IVF can lead to multiple pregnancies, such as twins or even triplets, Preimplantation Genetic Testing enables us to transfer a single embryo, helping you conceive one child at a time.

There are two forms of Preimplantation Genetic Testing called Preimplantation Genetic Diagnosis (PGD) and Preimplantation Genetic Screening (PGS).

Preimplantation Genetic Diagnosis (PGD)

If you have a known genetic condition such as Thalassemia or haemophilia, you may consider PGD. PGD at Sunfert International uses advance genetic technique called Karyomapping to select embryos free from genetic abnormalities so you can have a healthy baby.

We are particularly passionate about screening for Thalassemia, a serious blood condition in which one in 20 Malaysians are carriers, mainly of Chinese descent. When both parents are carriers, there is a 25% the child will have major Thalassemia. PGD stops the Thalassemia gene from being passed onto subsequent generations.

Preimplantation Genetic Diagnosis (PGD)

PGS is a technique we use as part of our NextGen IVF treatment to ensure that your embryos have the correct number of chromosomes to improve your chances of a successful pregnancy and having a healthy baby.

Statistics show that 1 in 5 pregnancies end in miscarriage and more than 50% are due to chromosomal abnormalities. Chromosomal abnormalities also cause

genetic conditions such as Down syndrome, Edward Syndrome, Patau Syndrome, Turner Syndrome and any sex-linked diseases.

PGS allows us to screen, select and transfer the strongest embryo free from Chromosomal abnormalities. It prevents multiple pregnancies as we are able to transfer a single embryo with the best chance of implantation, rather than transferring multiple embryos of varying quality.

For this reason, we recommend NextGen IVF for older couples, couples with a history of miscarriage or failed IVF, or couples who want to avoid multiple pregnancies while improving chances of success.