SCI论文投稿cover letter 投稿信模版

Dear editorial board of European Journal of Cardiology,

Please find enclosed the manuscript: “The angiotensin-converting enzyme is not a risk factor for myocardial infarction in French individuals”, by Sarah H., et al., to be subm itted as a Short Communication to the European Journal of Neurology for consideration of publication. All co-authors have seen and agree with the contents of the manuscript and there is no financial interest to report. We certify that the submission is original work and is not under review at any other publication.

In this manuscript, we report the results of the first study on the genetic and functional roles of the ACE on the risk of suffering a myocardial infarction in the French population. Indeed, we genotyped the rs4341 polymorphism in 531 IS cases and 549 healthy controls, and then performed functional studies by measuring serum ACE protein level and activity in healthy controls, stroke patients at baseline and stroke patients 24h after stroke symptoms onset. The results from our study did not reveal any association of the ACE variant with myocardial infarction, although it affected ACE protein level, and ischemic stroke patients showed lower ACE level than controls in the acute phase but not in the chronic phase.

We believe that our findings could be of interest to the readers of European Journal of Cardiology because they bring new and strong evidence that the ACE gene and protein are not a risk factor for myocardial infarction.

We hope that the editorial board will agree on the interest of this study.

Sincerely yours,

Sarah H. on behalf of the authors.

Corresponding author: Sarah Hamilton at Cardiovascular Research Laboratory, Marie Curie Research Institute, 75000, Paris, France, xxx@mariecurie.fr, phone number: +33582246xxx, fax number: +33582246xxx.

Case 1

Dear Editor,

We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.

GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.

Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am

Sincerely yours,

case2

Dear Editor,

We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron.

We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.

Sincerely yours,

Case 3

Sample Cover Letter[the example used is the IJEB]

Dear Editor of the [please type in journal title or acronym]:

Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the [journal title]. Below are our responses to your submission requirements.

1. Title and the central theme of the article.

Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in

a large network environment.

2. Which subject/theme of the Journal the material fits

New enabling technologies (if no matching subject/theme, enter 'Subject highly related to [subject of journal] but not listed by [please type in journal title or acronym])

3. Why the material is important in its field and why the material should be published in [please type in journal title or acronym]?

The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management system has become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobile

agent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acronym] readers to understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributed

network. We strongly believe the contribution of this study warrants its publication in the [journal title/acronym].

4. Names, addresses, and email addresses of four expert referees.

Prof. Dr. William Gates

Chair Professor of Information Technology

321 Johnson Hall

Premier University Lancaster, NY 00012-6666, USA

phone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail: wgates@https://www.360docs.net/doc/c914384702.html,

Expertise: published a related paper ("TCP/IP and OSI: Four Strategies for Interconnection") in CACM, 38(3), pp. 188-198.

Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally. Assoc Prof. Dr. John Adams

Director of Network Research Center

College of Business Australian University

123, Harbor Drive Sydney,

Australia 56789

phone: +61-8-8888-8888 - fax: +61-8-8888-8886

e-mail: jadams@https://www.360docs.net/doc/c914384702.html,.au

Expertise: published a related paper ("Creating Mobile Agents") in IEEE TOSE, 18(8), pp. 88-98. Relationship: None. I have never met Dr. Adams.

Assoc Prof. Dr. Chia-Ho Chen

Chair of MIS Department

College of Management

Open University

888, Putong Road

Keelung, Taiwan 100

phone: +886-2-8888-8888 - fax: +886-2-8888-8886

e-mail: chchen@https://www.360docs.net/doc/c914384702.html,.tw

Expertise: published a related paper ("Network Management for E-Commerce") in IJ Electronic Business, 1(4), pp. 18-28.

Relationship: Former professor, dissertation chairman.

Mr. Frank Young

Partner, ABC Consulting

888, Seashore Highway

Won Kok, Kowloon

Hong Kong

phone: +852-8888-8888 - fax: +852-8888-8886

e-mail: fyoung@https://www.360docs.net/doc/c914384702.html,

Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices.

Relationship: I have worked with Mr. Young in several consulting projects in the past three years.

Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.

Sincerely,

Johnny Smith

(完整版)英文投稿邮件写作模板

一、最初投稿Cover letter Dear Editors: We would like to submit the enclosed manuscript entitled “Paper Title”, which we wish to be considered for publication in “Journal Name”. No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed. In this work, we evaluated …… (简要介绍一下论文的创新性). I hope this paper is suitable for “Journal Name”. The following is a list of possible reviewers for your consideration: 1) Name A E-mail: ××××@×××× 2) Name B E-mail: ××××@×××× We deeply appreciate your consideration of our manuscript, and we look forward to receiving comments from the reviewers. If you have any queries, please don’t hesitate to contact me at the address below. Thank you and best regards. Yours sincerely, ×××××× Corresponding author: Name: ××× E-mail: ××××@×××× 二、催稿信 Dear Prof. ×××: Sorry for disturbing you. I am not sure if it is the right time to contact you to inquire about the status of my submitted manuscript titled “Paper Title”. (ID: 文章稿号), although the status of “With Editor” has been lasting for more than two months, since submitted to journal three months ago. I am just wondering that my manuscript has been sent to reviewers or not?

英文论文投稿信Coverletter模板

英文论文投稿信Cover letter模板 qiusuo BY - 2006-1-17 8:59:00 Dear Editor, We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience. GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease. Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours, case2 Dear Editor, We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron. We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a

SCI论文投稿有关各类回复信的写法

英文投稿中有关信件的写法一、投稿信 1. Dear Dr. Defendi ML: I am sending a manuscript entitled “” by – which I should like to submit for possible publication in the journal of - . Yours sincerely 2. Dear Dr. A: Enclosed is a manuscript entitled “” by sb, which we are submitting for pu blication in the journal of - . We have chosen this journal because it deals with - . We believe that sth would be of interest to the journal’s readers. 3. Dear Dr. A: Please find enclosed for your review an original research article, “” by sb. All author s have read and approve this version of the article, and due care has been taken to ensure the integrity of the work. No part of this paper has published or submitted elsewhere. No conflict of interest exits in the submission of this manuscript, and we have attached to this letter the signed letter granting us permission to use Figure 1 from another source. We appreciate your consideration of our manuscript, and we look forward to receiving comments from the reviewers. 二、询问有无收到稿件 Dear Editors, We dispatched our manuscript to your journal on 3 August 2006 but have not, as yet, receive acknowledgement of their safe arrival. We fear that may have been lost and should be grateful if you would let us know whether or not you have received them. If not, we will send our manuscript again. Thank you in advance for your help. 三、询问论文审查回音 Dear Editors， It is more than 12 weeks since I submitted our manuscript (No: ) for possible publication in your journal. I have not yet received a reply and am wondering whether you have reached a decision. I should appreciated your letting me know what you have decided as soon as possible. 四、关于论文的总体审查意见 1. This is a carefully done study and the findings are of considerable interest. A few minor revision are list below. 2. This is a well-written paper containing interesting results which merit p ublication. For the benefit of the reader, however, a number of points need clarifying and certain statements require further justification. There are given below. 3. Although these observation are interesting, they are rather limited and do not advance our

SCI论文投稿状态解析、修稿处理、拒稿后对策及接受后总结等全程荟萃

(一)投稿前准备工作和需要注意的事项、投稿过程相关经验总结投稿前准备工作和需要注意的事项：总结提示语：1)第一作者和通信作者的区别：通信作者(Corresponding author)通常是实际统筹处理投稿和承担答复审稿意见等工作的主导者，也常是稿件所涉及研究工作的负责人。通信作者的姓名多位列于论文作者名单的最后(使用符号来标识说明是Corresponding author)，但其贡献不亚于论文的第一作者。通讯作者往往指课题的总负责人，负责与编辑部的一切通信联系和接受读者的咨询等。文章的成果是属于通讯作者的，说明思路是通讯作者的，而不是第一作者。第一作者仅代表是你做的，且是最主要的参与者! 通信作者标注名称：Corresponding author，To whom correspondence should be addressed,或The person to whom inquiries regarding the paper should be addressed

若两个以上的作者在地位上是相同的，可以采取“共同第一作者”(joint first author)的署名方式，并说明These authors contributed equally to the work。 2)作者地址的标署：尽可能地给出详细通讯地址，邮政编码。有二位或多位作者，则每一不同的地址应按之中出现的先后顺序列出，并以相应上标符号的形式列出与相应作者的关系。如果第一作者不是通讯作者，作者应该按期刊的相关规定表达，并提前告诉编辑。期刊大部分以星号(*)、脚注或者致谢形式标注通讯联系人。 3)挑选审稿人的几个途径：很多SCI杂志都需要作者自己提出该篇论文的和您研究领域相关的审稿人，比较常见的是三名左右，也有的杂志要求5-8人。介绍几个方法： ①利用SCI、SSCI、A&HCI、ISTP检索和您研究相关的科学家; ②文章中的参考文献; ③相关期刊编委或学术会议的主席、委员;

SCI 投稿Cover letter模板大全

SCI 投稿Cover letter模板大全 1. 第一次投稿Cover letter：主要任务是介绍文章主要创新以及声明没有一稿多投 Dear Editors: We would like to submit the enclosed manuscript entitled “Paper Title”, which we wish to be considered for publication in “Journal Name”. No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed. In this work, we evaluated …… (简要介绍一下论文的创新性). I hope this paper is suitable for “Journal Name”. The following is a list of possible reviewers for your consideration: 1) Name A E-mail: ××××@×××× 2) Name B E-mail: ××××@×××× We deeply appreciate your consideration of our manuscript, and we look forward to receiving comments from the reviewers. If you have any queries, please don’t hesitate to contact me at the address below. Thank you and best regards. Yours sincerely, ××××××Corresponding author: Name: ××× E-mail: ××××@×××× 2. 催稿信：询问稿件处理到声明步骤 Dear Prof. ×××: Sorry for disturbing you. I am not sure if it is the right time to contact you to inquire about the status of my submitted manuscript titled “Paper Title”. (ID: 文章稿号), although the status of “With Editor” has been lasting for more than two months, since submitted to journal three months ago. I am just wondering that my manuscript

分享两篇SCI发表的经历(cover letter、response letter)

分享两篇SCI发表的经历三年前对于我来说SCI就是天书一样，在我踏进博士的门槛后我以为自己进入了地狱，也纠结也彷徨，整天刷虫友们对于博士、SCI的帖子，我选择了虫友们鼓励的那一部分来激励自己继续前行。我告诉自己坚持就是胜利，当然那是积极的坚持。在好几月之前就有这个想法，今天早上收到第二篇的接收通知后，我便想今天一定要在小木虫上谢谢那些给予我帮助的虫友们。话不多说，我把自己这两篇投稿的经历与大家共享，希望能给大家带来一点点用处。第一篇发表在Fitoterapia Cover letter Dear Editor Verotta: We would like to submit the manuscript entitled "××××××题目" by ××××××所有作者姓名which we wish to be considered for publication in Journal of Fitoterapia. All authors have read and approved this version of the article, and due care has been taken to ensure the integrity of the work. Neither the entire paper nor any part of its content has been published or has been accepted elsewhere. It is not being submitted to any other journal. We believe the paper may be of particular interest to the readers of your journal as it is the first time of ××××××研究的精华所在 Thank you very much for your reconsidering our revised manuscript for potential publication in Fitoterapia. We are looking forward to hearing from you soon. Correspondence should be addressed to Jinhui Yu at the following address, phone and fax number, and email address. 地址、学院、学校名称 Phone: + 86×××××× Fax number: + 86571××××××

投稿信coverletter和highlights模板

模板1 Dear Prof. XXXXX, Here within enclosed is our paper for consideration to be published on “(Journal name)”. The further information about the paper is in the following: The Title: XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX The Authors: XXXXXXXXXX XXXXXXXXXXXX and XXXXXXXXXX The authors claim that none of the material in the paper has been pub lished or is under consideration for publication elsewhere. I am the corresponding author and my address and other information is as follows,

Address: Department of XXXXXXXXX, Tsingh ua University, Beijin g, 10084, E-mail: Tel: 86- Fax: 86- Thank you very much for consideration! Sincerely Yours, Dr. XXXXXXXXXXX

模板2 Dear XX (Editor): Here is our paper submitted to "(XX Journal)". The Title: XXXX The Authors: XXX XXX and XXX In this paper, we ... The authors claim that none of the material in the paper has been published or is under consideration for publication elsewhere. The corresponding author is Dr. XXX and his address and other information is as following: Address: Department of XXX, XX University, ..., Tel: +86-xxx-xxxxxxxx

给一个答复审稿人意见的coverletter

给一个答复审稿人意见的coverletter,希望对大家有帮助 Cover letter Manuscript number: BXXXXXK MS Type: Article Title: "XXXX" Correspondence Author: XXX Dear Dr. Fay Riordan: Thank you very much for your attention and the referee’s evaluation and comments on our paper BXXXXK. We have revised the manuscript according to your kind advices and referee’s detailed suggestions. Enclosed please find the responses to the referees. We sincerely hope this manuscript will be finally acceptable to be published on XXX. Thank you very much for all your help and looking forward to hearing from you soon. Best regards Sincerely yours Dr. XXX Please find the following Response to the comments of referees: Response to the referee’s comments Referee A Comment 1: The titania material formed after calcining at 450 oC is not characterized. XRD of these calcined materials should be provided to understand the crystallinity and phase. Response: Thanks for the referee’s kind suggestion. According to his/her advices, X-ray diffractometry spectroscopy (XRD) of the calcined TiO2 film was given in Supporting Information (Figure S1) in this revised version. It illustrated that the hydrothermal synthesized TiO2 materials after calcining at 450 oC is entire anatase, which was confirmed by the X-ray diffractometer with Cu Kα radiation (Rigaku D/ max-2500). Comment 2: The authors must state the mechanical strength of these materials after the removal of PS by calcinations. Response: Thanks for the referee’s suggestion. By a scotch tape peel test, the TiO2 film can’t be stripped from the conducting glass substrate, which indicates that the mechanical strength of as-prepared composite film is strong enough for the fabrication of solar cell devices. The revised details can be found in Line 165-168, page 2. Referee B Comment 1: The microtube structure with the size of 500-800 nm cannot only scatter the visible light in the region of 500-800 nm, but also can scatter more efficiently the visible light in the region below 500 nm, and can scatter near infrared light. This point should be clarified in the main text. Response: Thanks for the referee’s kind advice. Just like what the referee said, the microtube network structure can scatter not only visible light but also near infrared light. We added this point in revised manuscript and the detailed revision can be found in Line 194-205, Page 2-3.

SCI论文投稿经验!

SCI论文投稿经验！ 2009年，我代表本课题组共投递7篇SCI论文（主要是生殖和神经方向），分别投往IF2.5—10分的杂志，经历了许多坎坷。不过，现在可喜的是已经accept了5篇，均在3分左右，revised 了2篇。在修稿和投稿过程中，本人学习了不少相关知识和积累了一些经验，现与各位战友分享，并请大家批评指正。内容清单： 1、本人2009年SCI投稿经验总结（含SCI投稿程序） 2、本版众多投稿相关精华帖汇聚 3、众多战友的2009年投稿经历汇总一、本人2009年SCI论文投稿步骤及其经验总结（一）投稿程序 1、选择合适的SCI期刊-Choose a journal。结合专业知识、2008或2007年度影响因子表和他人经验来综合选择要投递的期刊，并进入该期刊查询系统查询近年来的文章走向。 2、下载Introduction for submission。只要到每个杂志的首页，打开submit paper一栏，点击Introduction查看或下载即可。 3、稿件及其相关材料准备-Preparation：Manuscript.doc、Tables.doc、Figures.tiff（jpg 等）、Cover letter，有时还有Title page、Copyright agreement、Conflicts of interest等。 4、网上投稿-Submit a manuscript：先到每个杂志的首页，打开submit paper一栏，先以通讯作者的身份register一个账号，然后以author login身份登录，按照提示依次完成：Select Article Type、Enter Title、Add/Edit/Remove Authors、Submit Abstract、Enter Keywords、Select Classifications、Enter Comments、Request Editor、Attach Files，最后下载pdf，查看无误后，即可到投稿主页approve submission或直接submit it。 5、不定期关注稿件状态-Status：Submit New Manuscript、Submissions Sent Back to Author、Icomplete Submissions、Sbmissions Waiting for Author's Approval、Submissions Being Processed、Submissions Needing Revision、Rvisions Sent Back to Author、Icomplete Submissions Being Revised、Risions Waiting for Author's Approval、Revisions Being Processed、Declined Revisions。 6、修回稿的投递-Submitted the revised manuscript：主要修改revised manuscript、response to the reviewers、cover letter，还有其他修改的相关材料。程序是进入投稿主页main menu，点击revise，仍然按照原先程序投递（近似于4），切记把修改的标题、摘要和回复信等内容要修改。最后上传附件时，先把留下来且未修改的材料前打钩（表示留下不变），然后点击next，再上传已经修改的材料（主要包括revised manuscript、response to the reviewers、cover letter等），最后下载pdf，查看无误后，即可到投稿主页approve submission或直接submit it。

英文论文投稿邮件标准格式

Sample cover letter [Your Name] [Your Affiliation] [Your Address] [Date] Dear [Editor name], I/We wish to submit an original research article entitled “[title of article]” for consideration by [journal name]. I/We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper, I/we report on / show that _______. This is significant because __________. We believe that this manuscript is appropriate for publication by [journal name]because it… [specific re ference to the journal’s Aims & S cope]. __________. [Please explain in your own words the significance and novelty of the work, the problem that is being addressed, and why the manuscript belongs in this journal. Do not simply insert your abstract into your cover letter! Briefly describe the research you are reporting in your paper, why it is important, and why you think the readership of the journal would be interested in it.] We have no conflicts of interest to disclose. If you feel that the manuscript is appropriate for your journal, we suggest the following reviewers: [List reviewers and contact info, if requested by the journal] Please address all correspondence concerning this manuscript to me at [email address]. Thank you for your consideration of this manuscript. Sincerely, [Your name]

投稿coverletter写法

Case 1 Dear Editor, We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience. GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease. Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours, case2 Dear Editor, We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron. We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release. 某杂志给出的标准Sample Cover Letter Case 3 Sample Cover Letter Dear Editor of the : Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the . Below are our responses to your submission requirements. 1. Title and the central theme of the article. Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.